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Web Mood Changes, Sleep Problems (Insomnia); Too little estrogen can cause. Web fatigue and sleep issues estrogen is intimately linked to serotonin, and serotonin makes melatonin. Melatonin is the primary sleep hormone. Web When Estrogen Is Too High And Progesterone Too Low, It Can Cause Sleep Problems For The Obvious Reason—There Is Too Much Of The Excitatory Estrogen Compared To The Calming. Low levels of the sex hormone can cause sleep disturbances.
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